REPENTANCE - Dark Prince's Crown now grants more of an increase in rate of fire, and the bonus now breaks the soft tears cap. There are some unlocks tied to completing certain milestones on hard mode and some players do prefer to learn the game on hard so that they can unlock items quicker. Pressing 3 yellow buttons on the floor causes the minecart to be rideable. Can cause white poops through other item effects such as A Card Against Humanity or Re-Lax pills. Tap the drop button to cycle between each one, Changes all card and rune drops into pills. UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted ??? Tears now have a chance to cause enemies to be magnetized, Magnetized enemies attract other enemies, tears (including Isaac's) and enemy projectiles, causing them to be pulled in towards them, Enemy tears that get pulled into other enemies will hurt them, You have a chance to fire a tear that marks enemies red and slow them, Marked enemies will be attacked by other enemies either until it is killed or it kills all the other enemies attacking it, Chance to fire a marking tear scales with your luck stat, This item has a different effect for each character. This gives Isaac a bone sword and he goes on a killing rampage, gaining +0.4 Speed, +3 Flat Damage Up, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Samson, Activates the Mega Blast item effect, which gives you a giant laser that deals x5 your tear damage per tick to anything in its path and pushing Isaac back by the force, The effect lasts for 8 seconds but does persist between rooms, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Azazel, When used this kills Isaac and revives him with 1/2 a red heart. Flies spawned from a Mulligan dying, When used, the Mega Bean will freeze all enemies in the current room for a couple of seconds, deal 5 damage and poison any enemies in close proximity and send a wave of spikes across the room in the direction you are facing, The enemies in close range will take 5 damage then have a poison over time effect which deals your tear damage 4 or 6 times, The spike wave will deal 10 damage to any enemies in contact with it. yellow book how to, * boss room pool, boss room item, bone, red, brown, Gives Isaac a random tarot card when picked up, * boss room pool, boss room item, eight, grey, gray, Drops 4 random pills on the floor around Isaac, Item Pool: Shop, Boss Room, Challenge Room, Beggar, Demon Beggar, Mom's Chest, * dungeon room, blood challenge room, arena pool, demon beggar pool, demon judgement pool, devil beggar pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, shop room pool, shop item pool, bag, pouch, moms coin purse, mom coin purse. Great list! Cannot be rerolled by 4-pip dice rooms and Spindown Dice, Clearing a room will spawn an extra reward, however only one can be picked up - the other one will disappear, UNLOCK: Unlock this item by defeating the The Beast as Isaac, Every half red heart you pick up gives a small but permanent stat increase, Randomly picks between +0.10 Damage Up, +0.05 Tears Up, +0.15 Range Up, +0.02 Speed Up, +0.1 Luck Up, +0.02 Shot Speed Up per half red heart, UNLOCK: Unlock this item by defeating The Beast as Magdalene, This item causes Devil deals to cost money instead of hearts, and shop items to cost hearts instead of money, Shop items cost heart containers, and pickups have spikes around them, The Devil deal conversion rate is 1 heart container to 15 coins, Devil deal items can be on discount similar to the shop, making it 1 heart container = 7 coins instead, UNLOCK: Unlock this item by defeating The Beast as Cain, Every time you enter a devil room and choose not to take an item, you get +1 Damage Up upon entering the next floor, The effect is shown via a cross above Isaac's head. Spoon Bender, Telepathy for Dummies, I - The Magician), While held, gives you a small chance to gain a bone heart everytime you take damage, REPENTANCE - Finger Bone's chance to grant a bone heart has been increased to 5% per hit taken (from 2%), UNLOCK: Unlock this trinket by defeating Ultra Greed as The Forgotten, Teleports the player to the first room of the current floor, There is a guaranteed Fool card in the Depths 2, if you bomb the skull with an X on it. After a few seconds, the crosshair will disappear, and the Ghost will do certain things based on what you targeted: Items, pickups, trinkets: Brings them to Isaac. Fortune Cookie is good because of the low cost compared to other items like Crystal Ball. Summons Mom's foot which will stomp on a random enemy in the current room, dealing 300 damage, If no enemies are in the current room, the foot will target Isaac (and do damage if it hits), however it can be used to break rocks, Gives the player the Whore of Babylon effect for the current room, increasing damage and speed, Teleports the player to the Boss room on the current floor, *, the lost item pool, tarot, card, blue, red, If used in a Super Secret Room containing a Black Heart or Eternal Heart, it will spawn those types of hearts instead, Grants the same effect as 'My Little Unicorn', which makes Isaac invincible and deal 40 contact damage to enemies per hit, Spawns 1 bomb, 1 key, 1 coin, 1 heart, which can be random variants of each, On or below the Womb, this acts as a random teleport, since there are no shops on those floors, Spawns a Slot Machine or a Fortune Machine, Gives the player the Magic Mushroom effect, which increasing size and all stats by 1 for the current room, If you use the Strength card with 12 heart containers, it will take you down to 11 when you leave the room, Gives the player the flying effect for the current room, allowing the player to fly over obstacles in the room, This card is useless if you have any item which allows you to permanently fly, * , the lost item pool, tarot, card, grey, gray, Deals 40 damage to all enemies in the room in a similar style to the Necronomicon, * , the lost item pool, tarot, card, red, blue, Gives the Book of Belial effect for the current room, increasing damage, Spawns some troll bombs at random locations in the current room, Each bomb deals 60 damage (normal bomb damage, On or below the Womb, this acts as a random teleport, since there are no item rooms on those floors, A card with three uses: A full heal, deals 100 damage to all enemies in the current room and reveals the entire map for the current floor (Treasure Map + The Compass), Killing a Devil Beggar, Key Master, or Shell Game Beggar gives you an increased chance of finding Angel rooms instead of Devil rooms. The rock wave deals 10 damage. Function: Spending money gives out random stat boosts, Unlock Condition: Defeat Mother as Keeper. Stat Up becomes Stat Down), Any 'Stat down' pills you take give you a permanent +0.6 Damage Up (Horse pills +1.2), Most other pills spawn a black heart when used, including R U A Wizard?, Amnesia, Bad Trip, ?? Based on the Steam Workshop mod created by Strawrat and Aczom, UNLOCK: Unlock this item by dying to your own Ipecac explosion, Upon taking damage, you have a random chance to consume one of your currently held trinkets, gaining its effect permanently, Added as part of the Afterbirth+ Booster Pack #5. 1 = poop, 2 = penny, 3 = bomb, 4 = key, 5 = red heart, 6 = pill, 7 = card, 8 = soul heart, 9 = gold heart, 10 = gold key, 11 = gold bomb, At the full 12 charges, a completely random effect will happen. * arcade, skull game, black, heart, pink, love, Gives Isaac 2 orbital flies which block enemy shots, Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies, * item room, treasure room, item room pool, key master pool, key beggar pool, key judgement pool, two, flies, black, When revived, the green mushroom that follows Isaac will disappear and he will respawn with the same amount of red heart containers at full health, Resurrection takes place before all other items which give you an extra life, * secret room pool, mario, green mushroom, extra life, spots, spotted, x1.5 times Damage Multiplier (Does not stack with the multipliers from Cricket's Head / Blood of The Martyr + Book of Belial), Increases the size of your player sprite, but doesn't increase the hitbox, Counts as 1 of 3 mushroom items needed towards the Fun Guy transformation, Counts as 1 of 3 size-increasing items needed towards the Stompy transformation, * boss room pool, boss room item, item room, treasure room, item room pool, red, spots, spotted, amanita muscaria, Enemies touching you take 12 damage, then a poison effect is applied for 6-7 ticks, dealing damage equal to the amount of red hearts you have (up to 30.8 at 12 full red hearts), Has a chance to drop from the Lust miniboss fight, Counts as 1 of 3 syringe items needed towards the Spun transformation. He can pick up coins to restore health, Similar to other familiars of this kind, you can hold the drop key to cause him to stand still, If he dies, his corpse turns into a few blue spiders. 10 Magneto. Gives Isaac a little portal familiar, that moves across the screen as you're firing, The portal will suck up any consumables and trinkets it travels over, causing it to become larger and deal more contact damage, When the portal sucks up 4 pickups, it turns into a portal that can be used to teleport to unexplored rooms around the floor. He won't respawn even if you move to a new floor, Will always match your current movement speed, UNLOCK: Unlock this item by defeating The Beast as Tainted Keeper, Only found in the Mausoleum/Gehenna II boss room, The item itself has no effect, but triggers the ascent through the backwards path towards the Home floor. Subscribe. The item grants Isaac a fly follower that protects him from all enemy bullets, and it does that job almost too well. Explosion damage has increased to 100 (from 60). ), Doesn't show the location of Secret or Super Secret rooms, Room icons will not show if a Curse of the Lost is in effect on the current floor, * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, shop room pool, shop item pool, pink, red, Item Pool: Boss Room, Challenge Room, Beggar, * dungeon room, blood challenge room, arena pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, the lost item pool, brown, bowl, grey, gray, poop, fly, Item Pool: Boss Room, Beggar, Challenge Room, * dungeon room, blood challenge room, arena pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, the lost item pool, dog, can, tin, brown, * dungeon room, blood challenge room, arena pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, the lost item pool, dog, brown, sack, bag, fly, * dungeon room, blood challenge room, arena pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, the lost item pool, carton, fly, flies, milk, * dungeon room, blood challenge room, arena pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, the lost item pool, green, bone, lump, yellow. * e coli, item room, treasure room, item room pool, tampon, bloody, red, white, red sperm, ecoli, Isaac's tears turn into large scythes that pierce through enemies (Similar to how Death's scythes look), UNLOCK: Unlock this item by beating Challenge #17 (Waka Waka), * devil pool, devil room pool, devil deal, item room, treasure room, item room pool, axe, silver, ), *, money, silver, grey, gray, steam, smoke, cent, Everytime you pick up a coin, you have a 25% chance to spawn a key, *, white, grey, gray, coin, cent, money, cash, When picking up a coin, you have a chance to automatically gain one more coin, UNLOCK: Unlock this item by playing the shell game in the arcade 100 times, *, yellow, golden, coin, cent, money, cash, sparkle, When you enter a boss room, immediately remove 15% health from the boss and restore 1 red heart, This trinket cannot be dropped by holding the drop key or picking up other trinkets. and IBS also have special effects: Stone Dips deal 3.5 more damage and can take 6 hits before they die. 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